Hadi Sunaryo, Hadi dan Siska, Siska dan Hanani, Endang dan Anindita RS, Anindita dan Yanti N, Yanti dan Lisa, Lisa Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L. Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L..
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[24536725 - European Pharmaceutical Journal] Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L..pdf Download (354kB) | Preview |
Abstract
Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study
was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats.
The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory
activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract
(100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The
extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained
support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further
scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and
clinical settings.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Keguruan & Ilmu Pendidikan > Pendidikan Ekonomi |
| Depositing User: | Furqon FFS |
| Date Deposited: | 04 Feb 2020 09:15 |
| Last Modified: | 04 Feb 2020 09:15 |
| URI: | http://repository.uhamka.ac.id/id/eprint/876 |
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