THE EFFECT OF SODIUM ALGINATE CONCENTRATION ON GREEN TEA LEAF (Camellia sinensis L.) EXTRACT GEL AS TIROSINASE INHIBITOR

Hanifah, Rahmi dan Rizky Arcinthya Rachmania, Rizky dan Naniek Setiadi, Rajab THE EFFECT OF SODIUM ALGINATE CONCENTRATION ON GREEN TEA LEAF (Camellia sinensis L.) EXTRACT GEL AS TIROSINASE INHIBITOR. THE EFFECT OF SODIUM ALGINATE CONCENTRATION ON GREEN TEA LEAF (Camellia sinensis L.) EXTRACT GEL AS TIROSINASE INHIBITOR.

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Abstract

Green tea leaf (Camellia sinensis L.) is a great plant containing polyphenol compounds
such as catechin and gallocatechin gallate that can be used as tyrosinase inhibitors. In
this study, the green tea leaf extract made into gel dosage form using sodium alginate as
a gelling agent. This research aimed to determine the effect of different sodium alginate
concentrations on the physical stability of gel extract green leaf and to know the effect of
gel formulation on tyrosinase inhibition. Gel made into 3 formulas with each
concentration of sodium alginate of 2; 2.5; 3%. The extraction of green tea leaves was
performed by reflux using 50% methanol solvent. The results showed that the three
formulas did not occur in phase separation, and had IC50 values of 34.80, 23.27, 20.69
μg/mL. The conclusion is gel dosage form with 3% sodium alginate gave the best
inhibition of tyrosinase with IC50 of 20.69 μg/mL.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Keguruan & Ilmu Pendidikan > Pendidikan Ekonomi
Depositing User:	Furqon FFS
Date Deposited:	04 Feb 2020 09:15
Last Modified:	04 Feb 2020 09:15
URI:	http://repository.uhamka.ac.id/id/eprint/875

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