Citrus maxima Pectin as Superdisintegrant: Preparation and Evaluation of Dextromethorphan Hydrobromide Orodispersible Film

Nining, Nining dan Rahmah, Elfiyani dan Nurhasanah, Siti (2021) Citrus maxima Pectin as Superdisintegrant: Preparation and Evaluation of Dextromethorphan Hydrobromide Orodispersible Film. IOP Conference Series: Earth and Environmental Science, 755. pp. 1-9. ISSN 1755-1315

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Abstract

Citrus maxima pectin has a function to serve as a superdisintegrant due to its hydrophilicity, its high methoxyl content, and its great affinity for water. It allows the acceleration of the disintegration time of the orodispersible film. This study aims to determine the superdisintegration effect of Citrus maxima pectin on orodispersible film characteristics. Initially, Citrus maxima pectins were extracted and evaluated for organoleptic properties, qualitative tests, loss on drying, ash content, equivalent weight, and methoxyl content. Orodispersible film of dextromethorphan hydrobromide was formulated in 5 formulas with varying concentrations of 2%, 4%, 6%, 8%, and 10%. The films were evaluated for their organoleptic properties, uniformity of weight, thickness, tensile strength, elongation, pH, disintegration time, determination of content, and drug uniformity. The pectin from Citrus maxima has been successfully extracted to produce high purity and to include the type of HMP. Orodispersible film DH has been made and has met compendial standard parameters as they showed to have disintegration time of 48.5-59 seconds, a tensile strength of 20.59-32.45 kg/cm2, and elongation of 38.8-44%. The results showed that the increasing concentration of Citrus maxima pectin will accelerate the disintegration time, increase the elongation, and decrease the tensile strength.

Item Type:	Article
Subjects:	D History General and Old World > Fakultas Farmasi dan Sains
Divisions:	Fakultas Farmasi dan Sains > Farmasi
Depositing User:	Nining Nining
Date Deposited:	07 May 2021 13:27
Last Modified:	07 May 2021 13:27
URI:	http://repository.uhamka.ac.id/id/eprint/8454

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