Lusi, Putri Dwita dan Vivi Anggia, Vivi dan Tri Dewi Prasetyatuti, Tri Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate. Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate.
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Abstract
Background: The search for effective antidiabetic drugs remains to be a focus of research in the world.
Artocarpus have been used as traditional medicine in South-East Asia. One of the species, Artocarpus altilis
has been known in Indonesia as traditional treatment for diabetic. Objective: This research aimed to
discover α-amylase inhibitor activity of Artocarpus altilis leaves. Methods: Leaves were extracted by
maceration method, followed by phytochemical screening and quercetin identification using LC-MS
method. Inhibition of α-amylase was measured using UV-Vis spectrophotometer at 524 nm wavelength,
while antioxidant activity was determined using DPPH. Results: Artocarpus altilis leaves ethanol extract
exhibited activity against α-amylase with 155.96 ppm IC50 (0.27 times relative potential compared to
acarbose) and the extract showed antioxidant activity with the IC50 of 999.96 ppm. Conclusion: Artocarpus
altilis showed activity as the α-amylase inhibitor.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Keguruan & Ilmu Pendidikan > Pendidikan Ekonomi |
| Depositing User: | Furqon FFS |
| Date Deposited: | 19 Dec 2019 05:49 |
| Last Modified: | 19 Dec 2019 05:49 |
| URI: | http://repository.uhamka.ac.id/id/eprint/787 |
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