Rahma, Elfiyani dan Yudi, Srifiana dan Faisal Dharojat Al Rasyied, Faisal Curcumin encapsulation using dendrimer PAMAM G4 conjugated with polyethylene glycol to improve the properties of gel dossage form. Curcumin encapsulation using dendrimer PAMAM G4 conjugated with polyethylene glycol to improve the properties of gel dossage form. ISSN 2477 0256
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Abstract
Curcumin has a low bioavailability, therefore it needs to be encapsulated in the PAMAM dendrimer conjugated PEG to improve its bioavailability. To facilitate topical use, curcumin dendrimer was combined with a carbomer 940 that can produce hydration conditions in the stratum corneum to increase the bioavailability of curcumin. This study aimed to obtain the ratio between curcumin and dendrimer of PEG-conjugated PAMAM G4 in gel dosage form to produce the optimal of physical characteristics of dendrimer and physical stability of gel. The first step of this study was the formation of dendrimer of PEG-conjugated PAMAM G4 by using a ratio of 1: 5, and then encapsulated curcumin in dendrimer with a ratio of 1:0.2 (F1); 1:0.02 (F2) and 1:0.002 (F3). The next step was dendrimers formulated in a gel with a carbopol base 940. Evaluation of gel's physical characteristics were polydispersity index, zeta potential, particle size, organoleptic, flow properties, and pH at weeks 0, 2, 4 and 6. The results shows that F1 has zeta potential highest and the lowest viscosity of the other formula, while F3 has the lowest potential zeta and highest viscosity of other formulas. In addition, the polydispersity index, particle size, organoleptic, flow properties and pH; there are not a significant difference in each formula, but the particle size, zeta potential, and viscosity of gel can decrease with longer storage time. Conclusion of this study that the ratio 1 : 0.2 of curcumin and dendrimer of PEG-conjugated PAMAM G4 shows the optimal of physical characteristics of dendrimer and physical stability of gel.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Keguruan & Ilmu Pendidikan > Pendidikan Ekonomi |
| Depositing User: | Furqon FFS |
| Date Deposited: | 19 Dec 2019 05:49 |
| Last Modified: | 19 Dec 2019 05:49 |
| URI: | http://repository.uhamka.ac.id/id/eprint/777 |
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