Comparison eugenol and oleic acid as a plasticizer on characteristic of dextromethorphan hydrobromide film by solvent casting method

Nining, Nining dan Rahmah, Elfiyani dan Elvira, Wulandari (2021) Comparison eugenol and oleic acid as a plasticizer on characteristic of dextromethorphan hydrobromide film by solvent casting method. Pharmaceutical Sciences Asia, 48 (2). pp. 139-146. ISSN 2586-8470

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Abstract

Dextromethorphan hydrobromide (DH) is a cough suppressing drug as strongly as codeine but lasts longer. Orally dissolving film (ODF) from combination pomelo skin pectin and chitosan is strong but stiff. Formulation of the film added oleic acid and eugenol as a plasticizer was to improve tensile strength and elongation. This study aimed to compare the influences of plasticizer usage against the characteristics of DH film. Pectin of pomelo skin was extracted using the reflux method. Organoleptic properties, identification test, ash content, moisture content, equivalent weight, and methoxyl content was evaluated characteristic of pectin. DH film was produced using oleic acid (DHF-oleic acid) and eugenol (DHF-eugenol) on a concentration of 2%, 4%, and 6%. Organoleptic properties, uniformity weight,thickness, tensile strength, percent elongation, pH, disintegration time, determination level, and uniformity level was evaluated of film characteristic. The result of this study indicated that pectin characteristic conforms to requirements of high methoxyl form i.e., 7.43%. Evaluation results for both films showed organoleptic properties, uniformity weight, thickness, pH, and disintegration time have a similarity. Whereas tensile strength and percent elongation properties, DHF-eugenol has significantly different than DHF-oleic acid. In conclusion, eugenol as a plasticizer produced better film characteristics than oleic acid at all various concentrations on DH film.

Item Type:	Article
Subjects:	H Social Sciences
Divisions:	Fakultas Farmasi dan Sains
Depositing User:	Nining Nining
Date Deposited:	05 Mar 2021 11:09
Last Modified:	05 Mar 2021 11:09
URI:	http://repository.uhamka.ac.id/id/eprint/7045

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