Ari, Widayanti dan Rahmah, Elfiyani dan Dewi, Lestari Effect of Lecithin’s Concentration of Entrapment Vitamin E Acetate Liposomes Using Thin Layers Hydration Method. Effect of Lecithin’s Concentration of Entrapment Vitamin E Acetate Liposomes Using Thin Layers Hydration Method.
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Abstract
Tocopheryl acetate is not oxidized and can penetrate through the skin to the living cells, where about 5% is
converted to free tocopherol and provides beneficial antioxidant effects. Lecithin is one of the main components
of liposomes vesicles forming. The higher the phospholipid used, the more vesicles are formed, so that drug
use is also expected to be optimal. This study aims to determine the effect of increased lecithin concentration
on the efficiency of vitamin E application in liposomes made by thin layer hydration method. In this study
3 formulas were prepared using cholesterol and lecithin with a ratio of 20 mg each:100 mg (F I), 20 mg:400 mg
(F II) and 20 mg:700 mg (F III). Evaluation of liposomes, among others, the efficiency of adsorption, particle
size and morphology. The results showed the formulation of vitamin E in liposome using thin layer hydration
method obtained liposomal adsorption efficiency from F I to F III, respectively that is 41,3799%; 47.6162% and
52.7216%. It can be concluded that an increase in lecithin concentration may increase the efficiency of the
adsorption in which F III is the best formula for improving the efficiency of adsorption.
| Item Type: | Article |
|---|---|
| Subjects: | H Social Sciences |
| Divisions: | Fakultas Farmasi dan Sains |
| Depositing User: | Furqon FFS |
| Date Deposited: | 04 Feb 2019 02:42 |
| Last Modified: | 26 Oct 2020 07:36 |
| URI: | http://repository.uhamka.ac.id/id/eprint/619 |
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