YATI, KORI dan Elfiyani, Rahmah dan Hadi Kusuma, Galih (2015) FORMULATION AND PHYSICAL STABILITY NITROGLIYCERINE MICROEMULTION WITH TWEEN 80 AS SURFACTANT. In: The 2nd International Conference on Pharmaceutical Nanotechnology/Nanomedicine 2015, Jakarta, Indonesia.
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Abstract
Nitroglycerin is a drug of choice in the treatment of angina pectoris. Commonly used as buccal, sublingual
and injection. Sublingual treatment cause discomfort and sensation burning on its use. In this research used
forms microemulsion transdermal. Transdermal offers a way alternatives for the delivery of nitroglycerin
without passing through the intestines, so it is more convenient and safe for long term use. Microemulsion is
expected to increase the penetration of the drug because contains high concentrations of surfactants. This
research aims to determine the effect of the active agent nitroglycerin into microemulsion system and see its
physical stability and to obtain the best formulation. Used three variations of the concentration of tween 80,
there is 40%, 42.5% and 45%. Stability testing of physical properties during 8 weeks. From the results of
evaluation data showed that Formula 2 is the best formula with the result, among others, as The following pH
of 5.69 ± 0.01, the viscosity of 1480.26 ± 2.83 Cps, Specific Gravity of 1.0723 ± 0.00011 g / mL, Surface
Tension of 38.52 ± 0.037 dyne / cm and particle size of 77.95 nm.
Keywords: Tween 80, Mikroemulsi, Nitroglycerine, Transdermal
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Additional Information: | ISBN: 978-602-72418-3-1 |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Fakultas Keguruan & Ilmu Pendidikan > Pendidikan Ekonomi |
| Depositing User: | ST Bahar Sobari |
| Date Deposited: | 20 Jul 2018 01:37 |
| Last Modified: | 20 Jul 2018 01:37 |
| URI: | http://repository.uhamka.ac.id/id/eprint/535 |
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