Siska, Siska (2016) Antihypertensive and Diuretic E˦ects of The Ethanol Extract of Colocasia esculenta (L.) Schott. Leaves. Jurnal Ilmu Kefarmasian Indonesia, 14 (1). pp. 99-102. ISSN ISSN: 1693-1831 (print), 2614-6495
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Abstract
: Colocasia esculenta (L.) Schott (CE) is traditionally used for the treatment of various ailments
such as high blood pressure, diarrhea, rheumatic pain, pulmonary congestion, etc. Hence in the present
study, the effect of ethanol extract of CE leaves (EECE) was evaluated for antihypertensive and diuretic
activity in rats. Male Sprague Dawley rats were randomly divided into five groups (n=5), and treated as
follow: positive control group (hydrochlorothiazide 0.2569 mg/ 200 g BW), negative control (NaCl 8%)
and EECE (20, 40, and 80 mg/ 200 g BW) was given 14 days. The parameters systole blood pressure
(SBP) and diastole blood pressure (DBP) was estimated by Kent Scientific’s CODA Non-invasive Blood
Pressure on the days 0, 15, and 29. Diuretic activity of EECE was studied based on the volume of
urine for 6 hours and measuring the levels of sodium in urine 24 hours. The result of the study showed
that EECE 40 mg/ 200 g BW/ day significant (p<0.05) decreased in SBP 16.07% and in DBP 13.67%.
EECE 40 mg/ 200 g BW/day showed positive diuretic activity and significantly (p < 0.05) increased
sodium levels in urine. The preliminary phytochemical evaluation revealed the presence of saponins, tannin,
triterpenoid and flavonoids in EECE.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Fakultas Farmasi dan Sains |
| Depositing User: | Supandi Supandi |
| Date Deposited: | 06 Jan 2021 08:27 |
| Last Modified: | 28 Nov 2021 09:11 |
| URI: | http://repository.uhamka.ac.id/id/eprint/5103 |
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