Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.

Hadi Sunaryo, Hadi dan Siska, Siska Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L. EUROPEAN PHARMACEUTICAL JOURNAL.

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Abstract

Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study
was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats.
The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory
activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract
(100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The
extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained
support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further
scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and
clinical settings.

Item Type:	Article
Subjects:	D History General and Old World > Fakultas Farmasi dan Sains
Divisions:	Fakultas Farmasi dan Sains > Farmasi
Depositing User:	Furqon FFS
Date Deposited:	24 Nov 2025 08:22
Last Modified:	24 Nov 2025 08:22
URI:	http://repository.uhamka.ac.id/id/eprint/48479

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