Effect of Apium graveolens Extract Administration on the Pharmacokinetics of Captopril in the Plasma of Rats

Siska, Siska (2018) Effect of Apium graveolens Extract Administration on the Pharmacokinetics of Captopril in the Plasma of Rats. Scientia Pharmaceutica, 86(1). ISSN 22180532, 00368709

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Abstract

Apium graveolens (celery) is an edible and traditionally medicinal plant that is used
worldwide, among others for the treatment of hypertension. Combining celery with antihypertensive
drugs can affect the pharmacodynamics and pharmacokinetics of the latter drugs. The aim of the
study is to assess the effects of administrating the celery extract on captopril pharmacokinetics.
Sprague-Dawley strain rats were divided into two groups (n = 6). Group I was given captopril
(10 mg/kg Body Weight (BW)) orally, while Group II was pretreated with celery extract orally
(40 mg/kg BW) an hour before administration of captopril. The blood samples were withdrawn
at various intervals after drug administration. The captopril concentration was determined using
liquid chromatography–mass spectrometry (LC-MS/MS) and from the blood data, the values of Ke,
Cmax, Tmax, T1/2, and area under the curve (AUC) were calculated. The results showed that oral
administration of the celery extract increased Cmax (38.67%), T1/2 (37.84%), and AUC (58.10%) and
decreased Ke (27.45%) of captopril in Group II (celery + captopril) compared with Group I (captopril).
In conclusion, celery extract can alter the pharmacokinetic of captopril when given in combination.
The combination might be beneficial for the treatment of hypertension, as celery causes an increase in
the plasma level of captopril, which can enhance its efficacy

Item Type:	Article
Subjects:	Q Science > Q Science (General)
Depositing User:	admin repository uhamka
Date Deposited:	27 Feb 2018 04:19
Last Modified:	28 Nov 2021 10:22
URI:	http://repository.uhamka.ac.id/id/eprint/416

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