Microwave-assisted extraction of polyphenols from Eleutherine bulbosa Mill. Urb. bulbs using choline chloride-sorbitol based natural deep eutectic solvent

Siska, Siska (2023) Microwave-assisted extraction of polyphenols from Eleutherine bulbosa Mill. Urb. bulbs using choline chloride-sorbitol based natural deep eutectic solvent. Microwave-assisted extraction of polyphenols from Eleutherine bulbosa Mill. Urb. bulbs using choline chloride-sorbitol based natural deep eutectic solvent, 13 (6). pp. 217-224. ISSN 2231-3354

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Abstract

Eleutherine bulbosa Mill. Urb. is a potential plant to be developed as a raw pharmaceutical active ingredient. This
plant can be utilized as raw materials for herbal medicine production. A green solvent is one of the innovative
approaches to developing and utilizing natural products as a source of raw materials. This study aims to design and
optimize the microwave-assisted extraction (MAE) of polyphenols from E. bulbosa bulbs using choline chloride�sorbitol-based natural deep eutectic solvent (NADES). The MAE method with choline chloride and sorbitol as the
deep eutectic solvent composition was used to extract polyphenols content from E. bulbosa. Experimental design
with some independent variables was involved, including NADES (choline chloride-sorbitol) ratio, liquid-solid ratio,
microwave power, and extraction time. Response surface methodology with the Box-Behnken Design (using Design�Expert v12 program) was used to optimize the extraction condition based on the total polyphenols content (TPC) as
a dependent variable. TPC value was determined using the Folin–Ciocalteu reagent and measured using a UV–Vis
spectrophotometer at 761 nm. According to the study results, the optimum MAE condition was obtained at 1:1 g/g
NADES (choline chloride-sorbitol) ratio, 5 minutes extraction time, 20%W microwave power, and 12:1 ml/g liquid�solid ratio. A 50 g sample was extracted under the ideal MAE conditions for the scale-up confirmation test, yielding
a TPC value of 39.88 mgGAE/g sample. The MAE of polyphenols with choline chloride-sorbitol-based NADES
produced a higher TPC as a target secondary metabolite and was conducted efficiently, rapidly, and in an environment�friendly way.

Item Type:	Article
Subjects:	Q Science > Q Science (General)
Divisions:	Fakultas Farmasi dan Sains > Profesi Apoteker
Depositing User:	Supandi Supandi
Date Deposited:	17 Feb 2024 06:23
Last Modified:	17 Feb 2024 06:23
URI:	http://repository.uhamka.ac.id/id/eprint/33297

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Microwave-assisted extraction of polyphenols from Eleutherine bulbosa Mill. Urb. bulbs using choline chloride-sorbitol based natural deep eutectic solvent. (deposited 04 Aug 2023 04:03)
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