Siska, Siska (2023) Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats. Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats, 12 (3). pp. 448-452. ISSN 2345-5004
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Abstract
Introduction: The green cactus Pereskia bleo is thought to have anti-cancer, anti-tumor, anti�inflammatory, and anti-rheumatic properties. Additionally, it treats hypertension and diabetes;
However, no scientific evaluation of its antihypertensive activity has been conducted. The
purpose of this study was to investigate the effects of oral administration of P. bleo extract (PBE)
on male rats’ blood pressure, urine volume, and sodium and potassium levels.
Methods: Sodium chloride (NaCl) solution (4%) was administered orally to induce hypertension.
A non-invasive tail method was used to measure blood pressure. The sodium and potassium
concentrations as well as the total volume of urine were measured from the collected urine.
Results: Hypertensive rats’ blood pressure was reduced by 250, 500, and 1000 mg/kg of PBE.
Similar to the positive control group (captopril dose of 1.25 mg/kg BW), the most significant
drop in blood pressure was occurred at the dose of 1000 mg/kg BW (P>0.05). All treatment
groups saw an increase in urinary sodium and potassium levels.
Conclusion: In NaCl-induced hypertensive rats, oral administration of P. bleo ethanolic extract
decreased blood pressure to the standard value by increasing urinary sodium and potassium
levels. Hence, it might be used as an anti-hypertensive agent.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Fakultas Farmasi dan Sains > Profesi Apoteker |
| Depositing User: | Supandi Supandi |
| Date Deposited: | 17 Feb 2024 06:23 |
| Last Modified: | 17 Feb 2024 06:23 |
| URI: | http://repository.uhamka.ac.id/id/eprint/33295 |
Available Versions of this Item
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Effect of the ethanol extract of Pereskia bleo (Kunth)
DC. on the blood pressure and electrolyte levels of
hypertensive rats. (deposited 04 Aug 2023 07:35)
- Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats. (deposited 17 Feb 2024 06:23) [Currently Displayed]
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