Fahjar Prisiska, Fahjar ICOPS IIUM-SURAT TUGAS-BUKTI PEMBAYARAN-SERTIFIKAT KEGIATAN-GENAP-2021-2022. International Conference on Pharmaceutical Sciences ICOPS@IIUM2022 “Enhancement of Pharmacetical Efficacy Through Sustainable Research and Innovations”. (Unpublished)
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Abstract
In the manufacture of tablets, the use of Polyvinylpyrrolidone (PVP) as a binder
is common. PVP is a good binder for almost all types of tablets. In this study,
PVP was tried to be used as a binder on tablets with the active ingredient of dry
extract of red ginger added with zinc which is efficacious as an anti�atherosclerosis. The purpose of this study is to find out what is the optimum level
of PVP as a binder that will produce physically qualified tablets, namely on
hardness, brittleness, and time of disintegration. The experimental tablets were
made in 5 formulas with a range of PVP binding concentration of 2.8% to 3.9%.
Tablets are made by the wet granulation method, evaluated at the granulation
stage and the tablet stage. The results showed that the granules for all the
formulas made were qualified. The granule evaluation results which include
moisture content and flow properties are all qualified to be pressed into tablets.
The results of the tablet evaluation showed that of the five formulas tested for
hardness, brittleness, and the time of disintegration met the conditions according
to the reference used. If further observed from the data figures and based on the
results of statistical tests it was obtained that the one with the best physical
properties, namely the highest hardness with the fastest crushing time is in
formula 5. Thus, it can be concluded that the optimal binding formula of PVP on
ginger extract tablets with added zinc is 3.9%
| Item Type: | Article |
|---|---|
| Subjects: | A General Works A General Works > AI Indexes (General) |
| Depositing User: | Fahjar Prisiska |
| Date Deposited: | 02 Feb 2024 01:20 |
| Last Modified: | 02 Feb 2024 01:20 |
| URI: | http://repository.uhamka.ac.id/id/eprint/31976 |
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