Inding, Gusmayadi dan Ani Pahriyani, Ani dan Onny, Indriani (2015) EFFECT OF INCREASING HPMC CONCENTRATION ON PARTICULATE DISSOLUTION OF SOLID DISPERSION SYSTEM KETOPROFEN-HPMC. FFS UHAMKA. ISBN 978-602-71959-0-5
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Abstract
Ketoprofen is one of practically water insoluble drug compounds, the factor causing
dissolution and bioavailability the drugs is very low. To dissolve this problem, a
research was conducted by making solid dispersion system of ketoprofen using HPMC
as hydrophilic polymer. The ketoprofen solid dispersion was made in 5 combination i.e.
0%, 5%, 10%, 15%, and 20% of HPMC. Method of production of solid dispersion using
dissolving method, with ethanol 70% as solvent. The solid dispersions were
characterized for its crystal using thermal analyses by DSC (Differential Scanning
Calorimetry), and followed for dissolution using paddle-type method in HCl pH 1.2
buffer as medium. The results showed that increasing of HPMC increased ED
60
of
ketoprofen, whiles the maximum value at 10% HPMC concentration with ED
60
40.42%.
By one-way ANOVA analyses with 95% of significance level, among all combinations
showed a significant differences. On the other hand, thermal analyses results showed
that increasing of HPMC gave a slight decreasing melting point on solid dispersion
system ketoprofen-HPMC below pure ketoprofen. It could be concluded that HPMC is
less effective when used as a hydrophilic combination in solid dispersion.
| Item Type: | Book |
|---|---|
| Subjects: | D History General and Old World > Fakultas Farmasi dan Sains |
| Depositing User: | Mr. Inding Gusmayadi |
| Date Deposited: | 13 Apr 2023 09:05 |
| Last Modified: | 13 Apr 2023 09:05 |
| URI: | http://repository.uhamka.ac.id/id/eprint/23451 |
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