Gusmayadi, Inding dan Mulya Lestari, Pramulani (2019) VARIATION CONCENTRATION OF CITRIC ACID AS ACID SOURCES ON THE PHYSICAL PROPERTIES OF THE PERICARP MANGOSTEEN (Garcinia mangostana L) EXTRACTS EFFERVESCENT TABLET. International Journal of Pharmaceutics. ISSN 0378-5173 (Submitted)
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Abstract
Aim: Citric acid is an acid source in effervescent tablet which reacts rapidly with solvent. It
can increase dissolving time. In this research, extract was made into effervescent tablet. The
research aimed at knowing increased concentration of citric acid as acid source can improve
the physical characteristic of effervescent tablet.
Methods: Pericarp mangosteen macerated by water as solvent, and the extract was made into
powder by spray dryer method. Dry extract was made into 5 formulas effervescent tablet with
the different concentrations of citric acid, 15%, 20%, 25%, 30% and 35% as acid sources. The
evaluation of tablets quality included organoleptic evaluation, weight uniformity, size
uniformity, hardness, friability, and dissolving times.
Results: The result of dissolving time was subquently 10.50±0.57, 4.52±1.04, 3.32±0.13,
3.13±0.14, and 3.42±0.14 minutes. The value of dissolving time between the concentration of
citric acid were significanly different (ANOVA, p<0,05).
Conclusion: It can be concluded that the level of concentration of citric acid affected on
dissolving time of the pericarp mangosteen
(Garcinia mangostana L.) dry extract effervescent
tablets.
Keywords: Mangosteen, Effervescent tablet, Citric acid
| Item Type: | Article |
|---|---|
| Subjects: | H Social Sciences |
| Divisions: | Fakultas Farmasi dan Sains |
| Depositing User: | Mr. Inding Gusmayadi |
| Date Deposited: | 15 Aug 2020 06:58 |
| Last Modified: | 15 Aug 2020 06:58 |
| URI: | http://repository.uhamka.ac.id/id/eprint/1657 |
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