Anti-obesity Potency of Chili Extract in Male White Rat

Siska, Siska dan Bariroh, Tahyatul (2022) Anti-obesity Potency of Chili Extract in Male White Rat. Anti-obesity Potency of Chili Extract in Male White Rat, 9 (2). pp. 83-93. ISSN 2356-1971

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Abstract

Obesity is a global epidemic for non-communicable diseases characterized by a body mass index more
than 30 kg/m2
. Epidemiological data show that consuming foods containing capsaicin, the main active
compound and causes a spicy taste in chili associated with a decrease in the prevalence of obesity. This
study aims to determine the effect of consumption chili on lipid profile of rats fed high-fat diet and their
potential as anti-obesity. Treatment was conducted on 24 male Sprague-Dawley rats and divided into
6 groups namely the regular group (N) was given a standard diet and the group that was given a high�fat diet (PTL) and varied with a dose of 0.5 g/kg BW. Every 14 days of treatment, the weight of the
rats was weighed, and blood was taken retro-orbital to obtain the serum. The rat serum was tested for
total cholesterol (TC), triglycerides, LDL, and HDL through the colorimetric method. The levels were
assessed using a clinical spectrophotometer. The results showed a decrease in weight, LDL, increase
HDL (p<0.05), decrease in TC, triglyceride (p>0.05). This showed chili extract has the potential as an
anti-obesity with parameters of measuring lipid profile and weight but needs dose adjuster and timing
of extract administration.

Item Type:	Article
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Fakultas Farmasi dan Sains > Profesi Apoteker
Depositing User:	Supandi Supandi
Date Deposited:	26 Jul 2022 10:37
Last Modified:	26 Jul 2022 10:37
URI:	http://repository.uhamka.ac.id/id/eprint/15935

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