THE EFFECT OF SODIUM ALGINATE CONCENTRATION ON GREEN TEA LEAF (Camellia sinensis L.) EXTRACT GEL AS TIROSINASE INHIBITOR

Hanifah, RahmidanRizky Arcinthya Rachmania, RizkydanNaniek Setiadi, Rajab THE EFFECT OF SODIUM ALGINATE CONCENTRATION ON GREEN TEA LEAF (Camellia sinensis L.) EXTRACT GEL AS TIROSINASE INHIBITOR. THE EFFECT OF SODIUM ALGINATE CONCENTRATION ON GREEN TEA LEAF (Camellia sinensis L.) EXTRACT GEL AS TIROSINASE INHIBITOR.

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Abstract

Green tea leaf (Camellia sinensis L.) is a great plant containing polyphenol compounds such as catechin and gallocatechin gallate that can be used as tyrosinase inhibitors. In this study, the green tea leaf extract made into gel dosage form using sodium alginate as a gelling agent. This research aimed to determine the effect of different sodium alginate concentrations on the physical stability of gel extract green leaf and to know the effect of gel formulation on tyrosinase inhibition. Gel made into 3 formulas with each concentration of sodium alginate of 2; 2.5; 3%. The extraction of green tea leaves was performed by reflux using 50% methanol solvent. The results showed that the three formulas did not occur in phase separation, and had IC50 values of 34.80, 23.27, 20.69 μg/mL. The conclusion is gel dosage form with 3% sodium alginate gave the best inhibition of tyrosinase with IC50 of 20.69 μg/mL.

Item Type: Article
Subjects: Fakultas Agama Islam > R Medicine (General)
Fakultas Agama Islam > RS Pharmacy and materia medica
Divisions: Fakultas Keguruan & Ilmu Pendidikan > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 04 Feb 2020 09:15
Last Modified: 04 Feb 2020 09:15
URI: http://repository.uhamka.ac.id/id/eprint/875

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