FORMULATION AND PHYSICAL STABILITY NITROGLIYCERINE MICROEMULTION WITH TWEEN 80 AS SURFACTANT

YATI, KORI and Elfiyani, Rahmah and Hadi Kusuma, Galih (2015) FORMULATION AND PHYSICAL STABILITY NITROGLIYCERINE MICROEMULTION WITH TWEEN 80 AS SURFACTANT. In: The 2nd International Conference on Pharmaceutical Nanotechnology/Nanomedicine 2015, Jakarta, Indonesia.

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Abstract

Nitroglycerin is a drug of choice in the treatment of angina pectoris. Commonly used as buccal, sublingual and injection. Sublingual treatment cause discomfort and sensation burning on its use. In this research used forms microemulsion transdermal. Transdermal offers a way alternatives for the delivery of nitroglycerin without passing through the intestines, so it is more convenient and safe for long term use. Microemulsion is expected to increase the penetration of the drug because contains high concentrations of surfactants. This research aims to determine the effect of the active agent nitroglycerin into microemulsion system and see its physical stability and to obtain the best formulation. Used three variations of the concentration of tween 80, there is 40%, 42.5% and 45%. Stability testing of physical properties during 8 weeks. From the results of evaluation data showed that Formula 2 is the best formula with the result, among others, as The following pH of 5.69 ± 0.01, the viscosity of 1480.26 ± 2.83 Cps, Specific Gravity of 1.0723 ± 0.00011 g / mL, Surface Tension of 38.52 ± 0.037 dyne / cm and particle size of 77.95 nm. Keywords: Tween 80, Mikroemulsi, Nitroglycerine, Transdermal

Item Type: Conference or Workshop Item (Paper)
Additional Information: ISBN: 978-602-72418-3-1
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: ST Bahar Sobari
Date Deposited: 20 Jul 2018 01:37
Last Modified: 20 Jul 2018 01:37
URI: http://repository.uhamka.ac.id/id/eprint/535

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