VARIATION CONCENTRATION OF CITRIC ACID AS ACID SOURCES ON THE PHYSICAL PROPERTIES OF THE PERICARP MANGOSTEEN (Garcinia mangostana L) EXTRACTS EFFERVESCENT TABLET

Gusmayadi, IndingdanMulya Lestari, Pramulani (2019) VARIATION CONCENTRATION OF CITRIC ACID AS ACID SOURCES ON THE PHYSICAL PROPERTIES OF THE PERICARP MANGOSTEEN (Garcinia mangostana L) EXTRACTS EFFERVESCENT TABLET. International Journal of Pharmaceutics. ISSN 0378-5173 (Submitted)

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Abstract

Aim: Citric acid is an acid source in effervescent tablet which reacts rapidly with solvent. It can increase dissolving time. In this research, extract was made into effervescent tablet. The research aimed at knowing increased concentration of citric acid as acid source can improve the physical characteristic of effervescent tablet. Methods: Pericarp mangosteen macerated by water as solvent, and the extract was made into powder by spray dryer method. Dry extract was made into 5 formulas effervescent tablet with the different concentrations of citric acid, 15%, 20%, 25%, 30% and 35% as acid sources. The evaluation of tablets quality included organoleptic evaluation, weight uniformity, size uniformity, hardness, friability, and dissolving times. Results: The result of dissolving time was subquently 10.50±0.57, 4.52±1.04, 3.32±0.13, 3.13±0.14, and 3.42±0.14 minutes. The value of dissolving time between the concentration of citric acid were significanly different (ANOVA, p<0,05). Conclusion: It can be concluded that the level of concentration of citric acid affected on dissolving time of the pericarp mangosteen (Garcinia mangostana L.) dry extract effervescent tablets. Keywords: Mangosteen, Effervescent tablet, Citric acid

Item Type: Article
Subjects: Fakultas Farmasi dan Sains
Divisions: Fakultas Farmasi dan Sains
Depositing User: Mr. Inding Gusmayadi
Date Deposited: 15 Aug 2020 06:58
Last Modified: 15 Aug 2020 06:58
URI: http://repository.uhamka.ac.id/id/eprint/1657

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