Rizky Arcinthya Rachmania, Rizky dan Hariyanti, Hariyanti dan Nurul Rochmah, Nurul Molecular Docking Study of Lemon (Citrus limon (Linn) Burm. f) Flavonoid Derivatives Compound in Receptor Cyclooxygenase-1 (COX-1) as Antiplatelet in Ischaemic Stroke Disease. Molecular Docking Study of Lemon (Citrus limon (Linn) Burm. f) Flavonoid Derivatives Compound in Receptor Cyclooxygenase-1 (COX-1) as Antiplatelet in Ischaemic Stroke Disease.
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Abstract
Lemon (Citrus limon (Linn) Burm. f) is a plant that has efficacy as antiplatelet. Flavonoids in lemon
potentially obstruct COX-1 (Cyclooxygenase-1) receptor which has an important role in increasing
thromboxane A2 in the process of ischaemic stroke. This research aims at looking for flavonoids activity
from citrus lemon which is expected to be the antiplatelet drug candidates. The method used in this research
was the molecular docking method using Autodock Vina and Pymol software programs. The results showed
that the value of ΔG binding affinity Aspirin as the standard ligand was -6,5 kcal/mol and lemon flavonoid
derivatives that have the lowest ΔG binding affinity value was on Neohesperidin -15,4 kcal/mol and Rutin -
15,3 kcal/mol. This research shows that Neohesperidin and Rutin in lemon can be used as drug candidate of
antiplatelet in ischaemic stroke disease.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Keguruan & Ilmu Pendidikan > Pendidikan Ekonomi |
| Depositing User: | Furqon FFS |
| Date Deposited: | 19 Dec 2019 05:48 |
| Last Modified: | 19 Dec 2019 05:48 |
| URI: | http://repository.uhamka.ac.id/id/eprint/772 |
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