Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability

Lestari, Pramulani Mulya dan YATI, KORI dan Savira, Nanda (2018) Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability. Pharmaciana, 8 (1). pp. 119-128. ISSN 2088 4559; e-ISSN: 2477 0256

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As a drug delivery system, ketoconazole microemulsion in virgin coconut oil (oil phase) is
added with a thickening agent to create transdermal dosage form. This study aimed to compare the
physical stabilities of ketoconazole microemulsions formed with different thickeners, namely
Carbopol 934 and Carbopol 941. The formula used varying concentrations of Carbopol 934 and
Carbopol 941, i.e., 0.15% and 0.25%. The stability was observed during eight-week storage in which
the conditions were controlled by different degrees of temperature, i.e., 40C, 25-300C (room
temperature), and 400C. The stability tests included organoleptic observation, pH, surface tension,
viscosity, particle size, and zeta potential. Based on the Kruskal-Wallis test results, ketoconazole
microemulsion with Carbopol 941 that had been stored in different temperature showed a significant
difference in particle size (significance value< 0.05), but it did not apply to Carbopol 934. The
evaluation revealed that compared to 0.25% of Carbopol 934, microemulsion with 0.15% of Carbopol
934 had a smaller difference between the time intervals. This research concluded that the use of 0.15%
of Carbopol 934 as a thickener in ketoconazole microemulsion had better physical stability compared
to Carbopol 941 due to the influence of temperature and length of storage.

Item Type: Article
Uncontrolled Keywords: physical stability, ketoconazole microemulsion, thickener, Carbopol 934, and Carbopol 941
Subjects: R Medicine > RS Pharmacy and materia medica
Depositing User: ST Bahar Sobari
Date Deposited: 12 Sep 2018 07:38
Last Modified: 12 Sep 2018 07:38

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