Inding, Gusmayadi Optimization of polyvinylpyrrolidone concentration as a binder in red ginger dry extract tablets in combination with zinc sulfate. UHAMKA. (Unpublished)
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Abstract
Introduction: Polivinilpirolidon (PVP) one of binders which can obtain the tablet standard criteria, i.e hardness 3-6 KgF and friability less than 1%. Aims of this research to find out the optimum concentration of PVP as binder on ginger extract plus zink tablets.
Methods: The tablets are made in 5 formulas with PVP concentrations as binders of 2.8%, 3.1%, 3.4%, 3.7%, and 3.9%, respectively. The data observed on the evaluation of flow time granules, stationary angles, and compressibility, while for hardness and brittleness tablets.
Results and discussion: Based on the granule test results, the granule flow time obtained for formula 1 to formula 5 is qualified, formula 1 has the highest value compared to formulas 2, 3, 4, and 5. The results of the tablet test based on statistical analysis showed that the hardness for formula 1 was significantly different from formula 4, while formulas 1, 3, and 5 did not differ significantly. Shows that the hardness of formula 4 is the best. On the fragility test formula 1 is not qualified because the brittleness value is more than 1%. Furthermore, based on statistical tests for formula 2 and formula 3, it does not differ significantly, but formula 4 and formula 5 differ significantly, while formula 4 and formula 5 do not differ significantly but with formula 2 and formula 3 differ significantly, and the smallest brittleness value is in formula 5.
Conclusion: From this study, it can be concluded that the tablets that provide the best physical quality are formula 5 tablets with a PVP content of 3.9%..
| Item Type: | Other |
|---|---|
| Subjects: | D History General and Old World > Fakultas Farmasi dan Sains |
| Depositing User: | Mr. Inding Gusmayadi |
| Date Deposited: | 13 Feb 2023 01:00 |
| Last Modified: | 13 Feb 2023 01:00 |
| URI: | http://repository.uhamka.ac.id/id/eprint/20911 |
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