The combination of ginger (Zingiber officinale Rosc.) extract and zinc has the effect of
lowering levels of glucose. triglycerides. cholesterol and anti-oxidants. This study aimed
to determine the safety administration of combination ginger extract and zinc. through
the subchronic toxicity test. Parameters measured were body weight. liver and kidney
histopathology. SGOT. and SGPT. The study used a sample of 20 male mice. divided into
one control group and one treatment group. The extract was given orally through a sonde
for 75 days. The treatment group was given a combination of ginger extract and zinc
(ginger 30mg / 20g BW + zinc 0.4mg / 20g BW ) and the control group was given water.
After 75 days of treatment sample blood the heart and then checked SGOT and SGPT.
The collected statistical results with the method of independent samples T-test showed
no significant difference between the levels of SGOT and SGPT control group to the
treatment group. It can be concluded the combination of ginger extract and zinc did not show
any toxic effects in subchronic and did not cause toxicity and damage to vital organs, such as liver and kidney
Dimenhidrinat is one of active substance which can cure the pale. However, not all people can consume the tablet of dimenhidrinat easily. The difficulty to swallow tablet is a problem that happens. Therefore, the presence of ODT was absolutely needed because ODT can conceal the taste of dimenhidrinat (active substance) and help patients who have difficulty to swallow the tablet. The purpose of this research was to find out the usage of comparison for filler substance (manitol, lactose, and sucrose) toward the influence of characteristic’s ODT dimenhidrinat. This tablet was formulated by doing comparison manitol, lactose, sucrose
1:0:0, 0:1:0, 0:0:1, 1:1:0, 0:1:1, 1:0:1, 1:1:1. The tablet is made by direct molding method. From physical test of ODT like hardness test (2,2-4,7kg), friability (0,24-0,81%), weight uniformity (0,1825-0,2202 gram), modified shattered time (31,47-143,33 second), and ingredient uniformity test (95,35-108,18%). Based on Independent test with confidence level
95% (α= 0,05), the quickest shattered time is in formula 7 by comparison of filler substance manitol, lactose, and sucrose (1:1:1)
Keyword :Orally Disintegrating Tablet, Filler Substance, Dimenhidrinat