Introduction: Sterculia rubiginosa Zoll ex.Miq leaves have been used as traditional medicine
in Indonesia. There is no report about pharmacognosy and phytochemical study with this
plant.Objective: The main aim of this research is to establish pharmacognosy, phytochemical
study and antioxidant activity of Sterculia rubiginosa Zoll.ex. Miq. Leaves. The plant used to
cure many diseases of Indonesia. Methods: In the present study, pharmacognosy and phytochemical
study of plant material were performed as per the Indonesian Herb Pharmacopoeia.
Results: Microscopy powder of Sterculia rubiginosa Zoll.ex. Miq. Leaves shows star shape
trichoma as a specific fragment. Physicochemical parameters including total ash (17.152 %),
acid-insoluble ash (0.922 %), water-soluble extractive (1.610 % w/w), alcohol-soluble extractive
(4.524 % w/w), hexane-soluble extractive (4.005 % w/w), and ethyl acetate-soluble extractive
(3.160 % w/w) were evaluated. Phytochemical screening of ethanol extracts showed the
presence of tannins, flavonoids, alkaloids, steroids-terpenoids, glycosides, and phenols. And
absent of saponins and Anthraquinones. Antioxidant activity with IC50 157, 4665 ppm and
flavonoid total was 59.436 mg/g quercetin equivalent. Conclusion: The pharmacognosy,
physiochemical, and phytochemical evaluation provides information for the safety, identification,
and class of chemical constituent’s presents in this crude extract.