%0 Journal Article
%A Hadi Sunaryo, Hadi
%A Siska, Siska
%A Hanani, Endang
%A Anindita RS, Anindita
%A Yanti N, Yanti
%A Lisa, Lisa
%A UHAMKA,
%A UHAMKA,
%A UHAMKA,
%F repository:876
%I EUROPEAN PHARMACEUTICAL JOURNAL
%J Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.
%T Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.
%U http://repository.uhamka.ac.id/id/eprint/876/
%X Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study  was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats.  The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory  activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract  (100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The  extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained  support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further  scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and  clinical settings.