@article{repository876, title = {Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.}, journal = {Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.}, publisher = {EUROPEAN PHARMACEUTICAL JOURNAL}, abstract = {Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats. The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract (100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and clinical settings.}, url = {http://repository.uhamka.ac.id/id/eprint/876/}, author = {Hadi Sunaryo, Hadi and Siska, Siska and Hanani, Endang and Anindita RS, Anindita and Yanti N, Yanti and Lisa, Lisa} }