eprintid: 874
rev_number: 7
eprint_status: archive
userid: 1193
dir: disk0/00/00/08/74
datestamp: 2020-02-04 09:15:33
lastmod: 2020-02-04 09:15:33
status_changed: 2020-02-04 09:15:33
type: article
metadata_visibility: show
creators_name: Fitria Nugrahaeni, Fitria
creators_name: Dewi Melani Hariyadi, Dewi
creators_name: Noorma Rosita, Noorma
title: Partition Coefficient and Glutathione Penetration of Topical Antiaging: Preformulation Study
ispublished: pub
subjects: R1
subjects: RS
divisions: sch_med
abstract: Glutathione (GSH) is a broad antioxidant of the thiol-tripeptide group, highly hydrophilic, which has limitation for topical preparations. A lipophilic surfactant is an alternative method to enhance the glutathione partition. The purpose of this study was to determine the apparent partition coefficient (APC log) of glutathione; glutathione with additional surfactant at different HLB value of HLB 4.3; 5.5; 7; 11 and selected HLB was studied for penetration. The study was conducted by dissolving glutathione in water plus various HLB surfactants. Determination method of partition coefficient was done by shake flash method. The penetration test was conducted using the parameter of decreasing Matrix Metalloproteinase-1 expression on the balb-c male skin. The results can be used as a reference for topical glutathione formulations as these results are preformulation study.
publisher: International Journal of Drug Delivery Technology 2018
full_text_status: public
publication: Partition Coefficient and Glutathione Penetration of Topical Antiaging: Preformulation Study
refereed: TRUE
citation:   Fitria Nugrahaeni, Fitria dan Dewi Melani Hariyadi, Dewi dan Noorma Rosita, Noorma   Partition Coefficient and Glutathione Penetration of Topical Antiaging: Preformulation Study.  Partition Coefficient and Glutathione Penetration of Topical Antiaging: Preformulation Study.       
document_url: http://repository.uhamka.ac.id/id/eprint/874/1/IJDDT%2CVol8%2CIssue2%2CArticle1.pdf