eprintid: 870
rev_number: 7
eprint_status: archive
userid: 1193
dir: disk0/00/00/08/70
datestamp: 2020-02-04 09:15:26
lastmod: 2020-02-04 09:15:26
status_changed: 2020-02-04 09:15:26
type: article
metadata_visibility: show
creators_name: Nora Wulandari, Nora
creators_name: Maifitrianti, Maifitrianti
creators_name: Nila Yusmiati Ningsih, Nila
creators_id: wulandari.nora@gmail.com
creators_id: maifitrianti@uhamka.ac.id
corp_creators: UHAMKA
corp_creators: UHAMKA
title: Potential Drug-Drug Interaction and Actual Adverse Event in
Hospitalized Geriatric Patients with Chronic Kidney Disease
ispublished: pub
subjects: R1
subjects: RS
abstract: Chronic kidney disease (CKD) in Indonesia often occurs in elderly (geriatric) patients
with various complications that cause polypharmacy which can increase the risk of drug-drug
interactions (DDIs). This study aimed to determine the incidence of DDIs and actual adverse
events in geriatric patients with CKD. This was a descriptive study where the samples were
collected retrospectively from medical record of the patients admitted in one tertiary care hospital
in Jakarta. Potential drug interaction was screened electronically using a drug interaction
checker (drugs.com) and manually by Drug Interaction Fact 2014. A total of 699 potential DDIs
were detected from 135 patients from one-year study period. The incidence of DDIs was 92.60%
with 5.01% actual adverse event detected due to DDIs. Pharmacodynamic interactions
accounted for 46.64% with the most significant level at a moderate level (59.37%). In conclusion,
The prevalence of DDIs in geriatric patients with CKD was found high and major level of
significance adverse event hyperkalemia was found caused by the DDIs.
publisher: INTERNATIONAL CONFERENCE ON PHARMACEUTICAL RESEARCH AND PRACTICE
full_text_status: public
publication: Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease
refereed: TRUE
citation:   Nora Wulandari, Nora dan Maifitrianti, Maifitrianti dan Nila Yusmiati Ningsih, Nila   Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease.  Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease.       
document_url: http://repository.uhamka.ac.id/id/eprint/870/1/proceedings-icprp-uii-2018-halaman-148-152.pdf