%X Chronic kidney disease (CKD) in Indonesia often occurs in elderly (geriatric) patients
with various complications that cause polypharmacy which can increase the risk of drug-drug
interactions (DDIs). This study aimed to determine the incidence of DDIs and actual adverse
events in geriatric patients with CKD. This was a descriptive study where the samples were
collected retrospectively from medical record of the patients admitted in one tertiary care hospital
in Jakarta. Potential drug interaction was screened electronically using a drug interaction
checker (drugs.com) and manually by Drug Interaction Fact 2014. A total of 699 potential DDIs
were detected from 135 patients from one-year study period. The incidence of DDIs was 92.60%
with 5.01% actual adverse event detected due to DDIs. Pharmacodynamic interactions
accounted for 46.64% with the most significant level at a moderate level (59.37%). In conclusion,
The prevalence of DDIs in geriatric patients with CKD was found high and major level of
significance adverse event hyperkalemia was found caused by the DDIs.
%L repository870
%I INTERNATIONAL CONFERENCE ON PHARMACEUTICAL RESEARCH AND PRACTICE
%J Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease
%A Nora Nora Wulandari
%A Maifitrianti Maifitrianti
%A Nila Nila Yusmiati Ningsih
%T Potential Drug-Drug Interaction and Actual Adverse Event in
Hospitalized Geriatric Patients with Chronic Kidney Disease