%0 Journal Article %A Nora Wulandari, Nora %A Maifitrianti, Maifitrianti %A Nila Yusmiati Ningsih, Nila %A UHAMKA, %A UHAMKA, %F repository:870 %I INTERNATIONAL CONFERENCE ON PHARMACEUTICAL RESEARCH AND PRACTICE %J Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease %T Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease %U http://repository.uhamka.ac.id/id/eprint/870/ %X Chronic kidney disease (CKD) in Indonesia often occurs in elderly (geriatric) patients with various complications that cause polypharmacy which can increase the risk of drug-drug interactions (DDIs). This study aimed to determine the incidence of DDIs and actual adverse events in geriatric patients with CKD. This was a descriptive study where the samples were collected retrospectively from medical record of the patients admitted in one tertiary care hospital in Jakarta. Potential drug interaction was screened electronically using a drug interaction checker (drugs.com) and manually by Drug Interaction Fact 2014. A total of 699 potential DDIs were detected from 135 patients from one-year study period. The incidence of DDIs was 92.60% with 5.01% actual adverse event detected due to DDIs. Pharmacodynamic interactions accounted for 46.64% with the most significant level at a moderate level (59.37%). In conclusion, The prevalence of DDIs in geriatric patients with CKD was found high and major level of significance adverse event hyperkalemia was found caused by the DDIs.