%0 Journal Article
%A Nora Wulandari, Nora
%A Maifitrianti, Maifitrianti
%A Nila Yusmiati Ningsih, Nila
%A UHAMKA,
%A UHAMKA,
%F repository:870
%I INTERNATIONAL CONFERENCE ON PHARMACEUTICAL RESEARCH AND PRACTICE
%J Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease
%T Potential Drug-Drug Interaction and Actual Adverse Event in  Hospitalized Geriatric Patients with Chronic Kidney Disease
%U http://repository.uhamka.ac.id/id/eprint/870/
%X Chronic kidney disease (CKD) in Indonesia often occurs in elderly (geriatric) patients  with various complications that cause polypharmacy which can increase the risk of drug-drug  interactions (DDIs). This study aimed to determine the incidence of DDIs and actual adverse  events in geriatric patients with CKD. This was a descriptive study where the samples were  collected retrospectively from medical record of the patients admitted in one tertiary care hospital  in Jakarta. Potential drug interaction was screened electronically using a drug interaction  checker (drugs.com) and manually by Drug Interaction Fact 2014. A total of 699 potential DDIs  were detected from 135 patients from one-year study period. The incidence of DDIs was 92.60%  with 5.01% actual adverse event detected due to DDIs. Pharmacodynamic interactions  accounted for 46.64% with the most significant level at a moderate level (59.37%). In conclusion,  The prevalence of DDIs in geriatric patients with CKD was found high and major level of  significance adverse event hyperkalemia was found caused by the DDIs.