relation: http://repository.uhamka.ac.id/id/eprint/8538/
title: Direct Amidation of ethyl p-methoxycinnamate to Produce  N,N-bis-(2-hydroxyethyl)-p-methoxycinnamamide
creator: Supandi Supandi, Supandi
subject: Fakultas Farmasi dan Sains
description: Ethyl p-methoxycinnamate (EPMC) (1) is found as a major natural ester in the rhizome of Kaempferia galanga  (kencur) and has been known to have various pharmacological activities. The previous study has reported the  synthesis of N,N-bis-(2-hydroxyethyl)-p-methoxycinnamamide (2) by using microwave-assisted direct amidation  of EPMC (1) with diethanolamine. In this research, we attempt to synthesize of 2 by using a conventional direct  amidation of EPMC (1) with diethanolamine. The reaction was conducted without adding any coupling reagents  or catalyst. Structure of the synthetic product was determined by using analysis of GC-MS, IR, and 1H-NMR  spectroscopic data and then compared to the previously reported.
publisher: UIN Jakarta
date: 2018
type: Article
type: PeerReviewed
format: text
language: en
identifier: http://repository.uhamka.ac.id/id/eprint/8538/1/7300-22025-4-PB.pdf
identifier:   Supandi Supandi, Supandi  (2018) Direct Amidation of ethyl p-methoxycinnamate to Produce N,N-bis-(2-hydroxyethyl)-p-methoxycinnamamide.  valensi, 4 (1).  pp. 22-25.