eprintid: 8454
rev_number: 6
eprint_status: archive
userid: 1661
dir: disk0/00/00/84/54
datestamp: 2021-05-07 13:27:34
lastmod: 2021-05-07 13:27:34
status_changed: 2021-05-07 13:27:34
type: article
metadata_visibility: show
creators_name: Nining, Nining
creators_name: Rahmah, Elfiyani
creators_name: Nurhasanah, Siti
creators_id: nining@uhamka.ac.id
creators_id: rahmahelfiyani@uhamka.ac.id
creators_orcid: 0000-0003-1453-9237
creators_orcid: 0000-0002-9233-1557
title: Citrus maxima Pectin as Superdisintegrant: Preparation and Evaluation of Dextromethorphan Hydrobromide Orodispersible Film
ispublished: pub
subjects: D1
divisions: 48201
abstract: Citrus maxima pectin has a function to serve as a superdisintegrant due to its hydrophilicity, its high methoxyl content, and its great affinity for water. It allows the acceleration of the disintegration time of the orodispersible film. This study aims to determine the superdisintegration effect of Citrus maxima pectin on orodispersible film characteristics. Initially, Citrus maxima pectins were extracted and evaluated for organoleptic properties, qualitative tests, loss on drying, ash content, equivalent weight, and methoxyl content. Orodispersible film of dextromethorphan hydrobromide was formulated in 5 formulas with varying concentrations of 2%, 4%, 6%, 8%, and 10%. The films were evaluated for their organoleptic properties, uniformity of weight, thickness, tensile strength, elongation, pH, disintegration time, determination of content, and drug uniformity. The pectin from Citrus maxima has been successfully extracted to produce high purity and to include the type of HMP. Orodispersible film DH has been made and has met compendial standard parameters as they showed to have disintegration time of 48.5-59 seconds, a tensile strength of 20.59-32.45 kg/cm2, and elongation of 38.8-44%. The results showed that the increasing concentration of Citrus maxima pectin will accelerate the disintegration time, increase the elongation, and decrease the tensile strength.
date: 2021-05
date_type: published
publisher: IOP Publishing Ltd
official_url: https://iopscience.iop.org/article/10.1088/1755-1315/755/1/012045
id_number: https://doi.org/10.1088/1755-1315/755/1/012045
full_text_status: public
publication: IOP Conference Series: Earth and Environmental Science
volume: 755
pagerange: 1-9
refereed: TRUE
issn: 1755-1315
citation:   Nining, Nining dan Rahmah, Elfiyani dan Nurhasanah, Siti  (2021) Citrus maxima Pectin as Superdisintegrant: Preparation and Evaluation of Dextromethorphan Hydrobromide Orodispersible Film.  IOP Conference Series: Earth and Environmental Science, 755.  pp. 1-9.  ISSN 1755-1315     
document_url: http://repository.uhamka.ac.id/id/eprint/8454/1/Nining_2021_IOP_Conf._Ser.__Earth_Environ._Sci._755_012045_citrus%20maxima.pdf