eprintid: 815
rev_number: 7
eprint_status: archive
userid: 1193
dir: disk0/00/00/08/15
datestamp: 2019-12-19 05:50:25
lastmod: 2019-12-19 05:50:25
status_changed: 2019-12-19 05:50:25
type: article
metadata_visibility: show
creators_name: Elly Wardani, Elly
creators_name: Dwitiyanti, Dwitiyanti
creators_name: Sediarso, Sediarso
creators_name: Dwina Puspandiyah, Dwina
corp_creators: UHAMKA
corp_creators: UHAMKA
corp_creators: UHAMKA
title: Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan(Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters
ispublished: pub
subjects: R1
subjects: RS
divisions: sch_med
abstract: Diabetes mellitus is a disease characterized by hyperglycemia as well as progressive changes to the
pancreatic beta cell structure. This study was conducted to determine the antihyperglycemic activity of
ceplukan herb extract (Physalis angulata L.) in alloxan-induced male Syrian hamsters and high cholesterol
feed. The study used 24 hamsters divided into six groups. Group I were given a standard diet and regular
drinking water, Group II were given metformin dose 61,66 mg/kg body weight (BW), Group III were
alloxan-induced and high cholesterol feed, Groups IV, V and VI were given extract dose 60, 120 and 240
mg/kg BW respectively. The animals were induced alloxan monohydrate as well as were given high
cholesterol feed during treatment. Blood sampling was performed on the 29th and 44th day using a clinical
spectrophotometer. The results show significant differences between treatment groups (α <0,05), followed
by Tukey test. In conclusion, the preparation of herbal extract test ceplukan at doses of 120 and 240 mg/kg
BW could reduce blood glucose levels by 50.84% and 43.41% which is equivalent to metformin dose of
61.66 mg/kg BW with a percentage of 53.12%.
publisher: In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development (MICH-PhD 2018)
full_text_status: public
publication: Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan (Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters
refereed: TRUE
citation:   Elly Wardani, Elly dan Dwitiyanti, Dwitiyanti dan Sediarso, Sediarso dan Dwina Puspandiyah, Dwina   Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan(Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters.  Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan (Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters.       
document_url: http://repository.uhamka.ac.id/id/eprint/815/1/MICH-PhD_2018_23.pdf