eprintid: 7888
rev_number: 6
eprint_status: archive
userid: 1661
dir: disk0/00/00/78/88
datestamp: 2021-03-23 07:10:21
lastmod: 2021-03-23 07:10:21
status_changed: 2021-03-23 07:10:21
type: article
metadata_visibility: show
creators_name: Nining, Nining
creators_name: SRIFIANA, YUDI
creators_name: Fadlianty, Ely Malinda
creators_id: nining@uhamka.ac.id
creators_id: yudisrifiana@uhamka.ac.id
creators_orcid: 0000-0003-1453-9237
creators_orcid: 0000-0002-9233-1557
title: Preparation and characterization of enteric-coated delayed-release microsphere of phytosome loading allicin-rich extract
ispublished: pub
subjects: H
divisions: 12
abstract: Objective: Allicin, a natural organosulfur compound, is the main garlic ingredient, which has extensive pharmacological activities. Its unstable under acidic conditions due to alliinase's inactivation causes the need for preparations that delayed-release in the stomach to maximize allicin absorption. This study aimed to prepare and characterize the enteric-coated microsphere of phytosome loading allicin-rich extract to protect it from gastric acid.

Methods: The allicin-rich extract phytosome (ArE-Ps) was prepared and evaluated for characteristics. Microsphere was made in three formulas with different molar ratios of ArE-Ps and Eudragit L30D-55 (1:1; 1:1.5 and 1:2) by spray dry. The three microspheres compared to particle size, entrapment efficiency, and dissolution test in acid and 7.4 pH medium.

Results: Optimized ArE-Ps has a size of 251.6 nm, polydispersity index 0.466, zeta potential 34.11, entrapment efficiency of 62.62 %, and specific gravity of 1,005 g/ml. The surface topography of the three formulas shows an almost spherical shape with concave surfaces. The particle size of the microsphere ranges from 215±6.27 nm to 548.8±10.15 nm. Entrapment efficiency increases with an increasing number of polymers with a maximum value of 65.44 % at F3. The results dissolution test in vitro showed no drug release in acidic medium, and drug release occurred at a 7.4 pH medium. Drug release of three microsphere formulations followed the Korsmeyer-Peppas model with a k value of 12.7088±0.1769; 17.9322±1.5621; and 12.958±1.2677; respectively.

Conclusion: Based on these results, the polymer's increase in three microsphere formulations can affect characteristics and retain drug release under acidic conditions.
date: 2021-03-14
date_type: published
publisher: Innovare Academic Sciences
official_url: https://innovareacademics.in/journals/index.php/ijap/index
id_number: https://doi.org/10.22159/ijap.2021.v13s3.15
full_text_status: public
publication: International Journal of Applied Pharmaceutics (Int J App Pharm)
volume: 13
number: 03
pagerange: 71-75
refereed: TRUE
issn: 0975–7058
citation:   Nining, Nining dan SRIFIANA, YUDI dan Fadlianty, Ely Malinda  (2021) Preparation and characterization of enteric-coated delayed-release microsphere of phytosome loading allicin-rich extract.  International Journal of Applied Pharmaceutics (Int J App Pharm), 13 (03).  pp. 71-75.  ISSN 0975–7058     
document_url: http://repository.uhamka.ac.id/id/eprint/7888/1/IJAP%202021.pdf