<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Preparation and characterization of enteric-coated delayed-release microsphere of phytosome loading allicin-rich extract"^^ . "Objective: Allicin, a natural organosulfur compound, is the main garlic ingredient, which has extensive pharmacological activities. Its unstable under acidic conditions due to alliinase's inactivation causes the need for preparations that delayed-release in the stomach to maximize allicin absorption. This study aimed to prepare and characterize the enteric-coated microsphere of phytosome loading allicin-rich extract to protect it from gastric acid.\r\n\r\nMethods: The allicin-rich extract phytosome (ArE-Ps) was prepared and evaluated for characteristics. Microsphere was made in three formulas with different molar ratios of ArE-Ps and Eudragit L30D-55 (1:1; 1:1.5 and 1:2) by spray dry. The three microspheres compared to particle size, entrapment efficiency, and dissolution test in acid and 7.4 pH medium.\r\n\r\nResults: Optimized ArE-Ps has a size of 251.6 nm, polydispersity index 0.466, zeta potential 34.11, entrapment efficiency of 62.62 %, and specific gravity of 1,005 g/ml. The surface topography of the three formulas shows an almost spherical shape with concave surfaces. The particle size of the microsphere ranges from 215±6.27 nm to 548.8±10.15 nm. Entrapment efficiency increases with an increasing number of polymers with a maximum value of 65.44 % at F3. The results dissolution test in vitro showed no drug release in acidic medium, and drug release occurred at a 7.4 pH medium. Drug release of three microsphere formulations followed the Korsmeyer-Peppas model with a k value of 12.7088±0.1769; 17.9322±1.5621; and 12.958±1.2677; respectively.\r\n\r\nConclusion: Based on these results, the polymer's increase in three microsphere formulations can affect characteristics and retain drug release under acidic conditions."^^ . "2021-03-14" . . . "13" . "03" . . "Innovare Academic Sciences"^^ . . . "International Journal of Applied Pharmaceutics (Int J App Pharm)"^^ . . . "09757058" . . . . . . . . . . . . . "Nining"^^ . "Nining"^^ . "Nining Nining"^^ . . "Ely Malinda"^^ . "Fadlianty"^^ . "Ely Malinda Fadlianty"^^ . . "YUDI"^^ . "SRIFIANA"^^ . "YUDI SRIFIANA"^^ . . . . . . "Preparation and characterization of enteric-coated delayed-release microsphere of phytosome loading allicin-rich extract (Text)"^^ . . . "IJAP 2021.pdf"^^ . . . "Preparation and characterization of enteric-coated delayed-release microsphere of phytosome loading allicin-rich extract (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Preparation and characterization of enteric-coated delayed-release microsphere of phytosome loading allicin-rich extract (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Preparation and characterization of enteric-coated delayed-release microsphere of phytosome loading allicin-rich extract (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Preparation and characterization of enteric-coated delayed-release microsphere of phytosome loading allicin-rich extract (Other)"^^ . . . . . . "small.jpg"^^ . . . "Preparation and characterization of enteric-coated delayed-release microsphere of phytosome loading allicin-rich extract (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #7888 \n\nPreparation and characterization of enteric-coated delayed-release microsphere of phytosome loading allicin-rich extract\n\n" . "text/html" . . . "H Social Sciences"@en . .