eprintid: 787
rev_number: 7
eprint_status: archive
userid: 1193
dir: disk0/00/00/07/87
datestamp: 2019-12-19 05:49:24
lastmod: 2019-12-19 05:49:24
status_changed: 2019-12-19 05:49:24
type: article
metadata_visibility: show
creators_name: Lusi, Putri Dwita
creators_name: Vivi Anggia, Vivi
creators_name: Tri Dewi Prasetyatuti, Tri
creators_id: lusiputridwita@gmail.com
corp_creators: UHAMKA
corp_creators: UHAMKA
title: Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate
ispublished: pub
subjects: R1
subjects: RS
divisions: sch_med
abstract: Background: The search for effective antidiabetic drugs remains to be a focus of research in the world.
Artocarpus have been used as traditional medicine in South-East Asia. One of the species, Artocarpus altilis
has been known in Indonesia as traditional treatment for diabetic. Objective: This research aimed to
discover α-amylase inhibitor activity of Artocarpus altilis leaves. Methods: Leaves were extracted by
maceration method, followed by phytochemical screening and quercetin identification using LC-MS
method. Inhibition of α-amylase was measured using UV-Vis spectrophotometer at 524 nm wavelength,
while antioxidant activity was determined using DPPH. Results: Artocarpus altilis leaves ethanol extract
exhibited activity against α-amylase with 155.96 ppm IC50 (0.27 times relative potential compared to
acarbose) and the extract showed antioxidant activity with the IC50 of 999.96 ppm. Conclusion: Artocarpus
altilis showed activity as the α-amylase inhibitor.
publisher: In Proceedings of BROMO Conference (BROMO 2018)
full_text_status: public
publication: Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate
refereed: TRUE
citation:   Lusi, Putri Dwita dan Vivi Anggia, Vivi dan Tri Dewi Prasetyatuti, Tri   Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate.  Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate.       
document_url: http://repository.uhamka.ac.id/id/eprint/787/1/BROMO_2018_26.pdf