TY  - JOUR
PB  - In Proceedings of BROMO Conference (BROMO 2018)
A1  - Lusi, Putri Dwita
A1  - Vivi Anggia, Vivi
A1  - Tri Dewi Prasetyatuti, Tri
TI  - Artocarpus altilis Leaves Activity in Inhibiting ?-Amylase Enzyme as Oral Antidiabetic Drug Candidate
UR  - http://repository.uhamka.ac.id/id/eprint/787/
AV  - public
N2  - Background: The search for effective antidiabetic drugs remains to be a focus of research in the world.
Artocarpus have been used as traditional medicine in South-East Asia. One of the species, Artocarpus altilis
has been known in Indonesia as traditional treatment for diabetic. Objective: This research aimed to
discover ?-amylase inhibitor activity of Artocarpus altilis leaves. Methods: Leaves were extracted by
maceration method, followed by phytochemical screening and quercetin identification using LC-MS
method. Inhibition of ?-amylase was measured using UV-Vis spectrophotometer at 524 nm wavelength,
while antioxidant activity was determined using DPPH. Results: Artocarpus altilis leaves ethanol extract
exhibited activity against ?-amylase with 155.96 ppm IC50 (0.27 times relative potential compared to
acarbose) and the extract showed antioxidant activity with the IC50 of 999.96 ppm. Conclusion: Artocarpus
altilis showed activity as the ?-amylase inhibitor.
JF  - Artocarpus altilis Leaves Activity in Inhibiting ?-Amylase Enzyme as Oral Antidiabetic Drug Candidate
ID  - repository787
ER  -