%0 Journal Article
%A Lusi, Putri Dwita
%A Vivi Anggia, Vivi
%A Tri Dewi Prasetyatuti, Tri
%A UHAMKA,
%A UHAMKA,
%F repository:787
%I In Proceedings of BROMO Conference (BROMO 2018)
%J Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate
%T Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate
%U http://repository.uhamka.ac.id/id/eprint/787/
%X Background: The search for effective antidiabetic drugs remains to be a focus of research in the world.  Artocarpus have been used as traditional medicine in South-East Asia. One of the species, Artocarpus altilis  has been known in Indonesia as traditional treatment for diabetic. Objective: This research aimed to  discover α-amylase inhibitor activity of Artocarpus altilis leaves. Methods: Leaves were extracted by  maceration method, followed by phytochemical screening and quercetin identification using LC-MS  method. Inhibition of α-amylase was measured using UV-Vis spectrophotometer at 524 nm wavelength,  while antioxidant activity was determined using DPPH. Results: Artocarpus altilis leaves ethanol extract  exhibited activity against α-amylase with 155.96 ppm IC50 (0.27 times relative potential compared to  acarbose) and the extract showed antioxidant activity with the IC50 of 999.96 ppm. Conclusion: Artocarpus  altilis showed activity as the α-amylase inhibitor.