eprintid: 773
rev_number: 8
eprint_status: archive
userid: 1193
dir: disk0/00/00/07/73
datestamp: 2019-12-19 05:48:50
lastmod: 2019-12-19 05:48:50
status_changed: 2019-12-19 05:48:50
type: article
metadata_visibility: show
creators_name: Hariyanti, Hariyanti
creators_name: Rizky Arcinthya Rachmania, Rizky
creators_name: Mutia Karinah, Mutia
creators_name: Hadi Sunaryo, Hadi
creators_id: hadisunaryo@uhamka.ac.id
corp_creators: UHAMKA
corp_creators: UHAMKA
corp_creators: UHAMKA
title: In Silico Analysis of the Phytochemical Compounds in Carica papaya
Seeds for Optimizing the Inhibitors of HMG-CoA Reductase
ispublished: pub
subjects: R1
subjects: RS
divisions: sch_med
abstract: HMG-CoA Reductase, a key enzyme in the cholesterol biosynthesis, catalyzes the conversion of 3-
hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) into mevalonate. Therefore, this enzyme is the target
of the cholesterol-lowering drugs known as statins. Carica papaya seed extract contains phytochemical
compounds that are thought to have a cholesterol-lowering effect. The present study was designed to
examine the ability of the secondary metabolites of Carica papaya seeds as an antagonist to HMG-CoA
reductase using in silico molecular docking. The docking analysis was carried out in PLANTS 1.2 software
in which the lowest ChemPLP score, i.e., free energy, was the molecular docking parameter. Seven ligands
were docked with HMG-CoA reductase receptor, three of which were benzyl glucosinolate, oleic acid, and
glucotropaeolin that had the best ChemPLP scores, namely -90.5491 kcal/mol, -81.7665kcal/mol, and -
85.1919 kcal/mol, respectively. Benzyl glucosinolate formed hydrogen bonds with the active site of the
targeted protein. As a conclusion, this compound can inhibit the enzyme HMG-CoA reductase, and it has
the potential for anti-hypercholesterolemia.
publisher: In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development (MICH-PhD 2018)
full_text_status: public
publication: In Silico Analysis of the Phytochemical Compounds in Carica papaya Seeds for Optimizing the Inhibitors of HMG-CoA Reductase
refereed: TRUE
citation:   Hariyanti, Hariyanti dan Rizky Arcinthya Rachmania, Rizky dan Mutia Karinah, Mutia dan Hadi Sunaryo, Hadi   In Silico Analysis of the Phytochemical Compounds in Carica papaya Seeds for Optimizing the Inhibitors of HMG-CoA Reductase.  In Silico Analysis of the Phytochemical Compounds in Carica papaya Seeds for Optimizing the Inhibitors of HMG-CoA Reductase.       
document_url: http://repository.uhamka.ac.id/id/eprint/773/1/MICH-PhD_2018_22.pdf