eprintid: 772
rev_number: 7
eprint_status: archive
userid: 1193
dir: disk0/00/00/07/72
datestamp: 2019-12-19 05:48:47
lastmod: 2019-12-19 05:48:47
status_changed: 2019-12-19 05:48:47
type: article
metadata_visibility: show
creators_name: Rizky Arcinthya Rachmania, Rizky
creators_name: Hariyanti, Hariyanti
creators_name: Nurul Rochmah, Nurul
corp_creators: UHAMKA
title: Molecular Docking Study of Lemon (Citrus limon (Linn) Burm. f)
Flavonoid Derivatives Compound in Receptor Cyclooxygenase-1
(COX-1) as Antiplatelet in Ischaemic Stroke Disease
ispublished: pub
subjects: R1
subjects: RS
divisions: sch_med
abstract: Lemon (Citrus limon (Linn) Burm. f) is a plant that has efficacy as antiplatelet. Flavonoids in lemon
potentially obstruct COX-1 (Cyclooxygenase-1) receptor which has an important role in increasing
thromboxane A2 in the process of ischaemic stroke. This research aims at looking for flavonoids activity
from citrus lemon which is expected to be the antiplatelet drug candidates. The method used in this research
was the molecular docking method using Autodock Vina and Pymol software programs. The results showed
that the value of ΔG binding affinity Aspirin as the standard ligand was -6,5 kcal/mol and lemon flavonoid
derivatives that have the lowest ΔG binding affinity value was on Neohesperidin -15,4 kcal/mol and Rutin -
15,3 kcal/mol. This research shows that Neohesperidin and Rutin in lemon can be used as drug candidate of
antiplatelet in ischaemic stroke disease.
publisher: In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development (MICH-PhD 2018)
full_text_status: public
publication: Molecular Docking Study of Lemon (Citrus limon (Linn) Burm. f) Flavonoid Derivatives Compound in Receptor Cyclooxygenase-1 (COX-1) as Antiplatelet in Ischaemic Stroke Disease
refereed: TRUE
citation:   Rizky Arcinthya Rachmania, Rizky dan Hariyanti, Hariyanti dan Nurul Rochmah, Nurul   Molecular Docking Study of Lemon (Citrus limon (Linn) Burm. f) Flavonoid Derivatives Compound in Receptor Cyclooxygenase-1 (COX-1) as Antiplatelet in Ischaemic Stroke Disease.  Molecular Docking Study of Lemon (Citrus limon (Linn) Burm. f) Flavonoid Derivatives Compound in Receptor Cyclooxygenase-1 (COX-1) as Antiplatelet in Ischaemic Stroke Disease.       
document_url: http://repository.uhamka.ac.id/id/eprint/772/1/MICH-PhD_2018_4.pdf