eprintid: 751
rev_number: 12
eprint_status: archive
userid: 1193
dir: disk0/00/00/07/51
datestamp: 2019-12-18 04:57:12
lastmod: 2020-11-02 08:37:08
status_changed: 2019-12-18 04:57:12
type: article
metadata_visibility: show
creators_name: Dwitiyanti, Dwitiyanti
creators_name: Ni Putu Ermi Hikmawati, Ermi
creators_name: Kriana, Efendi
creators_name: Riana Puspa Dewi, Riana
creators_name: Fernita Afriyani, Fernita
creators_id: ermy0907@uhamka.ac.id
creators_id: krianaefendi@gmail.com
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0002-9233-1557
corp_creators: UHAMKA
corp_creators: UHAMKA
corp_creators: UHAMKA
title: Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona
palustris Blume Leaves on Male Hamsters
ispublished: pub
subjects: H
divisions: 12
abstract: In Indonesia, Mesona palustris Blume is known as the black cincau (black grass jelly). This plant has
been used for various health condition. This study aims to determine the effectiveness of 70% ethanol
extract from black cincau leaves as anti-hyperlipidemic on hyperlipidemic hamsters. The dried leaves
were extracted using 70% ethanol by maceration method. Syrian hamsters were divided into 7 groups of 4
hamsters), i.e. normal control group, positive control group (fenofibrate 1.235 mg/Kg body weight), positive
control group (atorvastatin 2.4 mg/Kg body weight), negative control group, test groups with 3 dose
variations (780, 1560, and 3120 mg/Kg body weight each day). All groups except normal control group
were induced with high-fat diet for 28 days. Parameters measured were decreased total blood cholesterol,
LDL, triglycerides level, and increased blood HDL level. Treatment was performed for 14 days. The 70%
ethanol extract of black cincau with a dose of 3120 mg/Kg body weight was able to decrease blood total
cholesterol level by 51.49%, blood LDL level by 49.92%, and blood triglyceride level by 45.70%. Extract
with the dose is also able to increase blood HDL level by 29.30%. Fenofibrate was able to decrease blood
triglyceride level by 50.62% and increase blood HDL level by 34.82%, whereas atorvastatin was able to
decrease blood total cholesterol level by 54.34% and blood LDL level by 51.13%. It could be concluded
that the 70% ethanol extract from black cincau leaves is effective as an anti-hyperlipidemic agent in
hyperlipidemic hamster equivalent to positive control group.
publisher: In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development (MICH-PhD 2018)
full_text_status: public
publication: Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters
refereed: TRUE
citation:   Dwitiyanti, Dwitiyanti dan Ni Putu Ermi Hikmawati, Ermi dan Kriana, Efendi dan Riana Puspa Dewi, Riana dan Fernita Afriyani, Fernita   Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters.  Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters.       
document_url: http://repository.uhamka.ac.id/id/eprint/751/1/MICH-PhD_2018_11.pdf