%L repository751
%I In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development (MICH-PhD 2018)
%A Dwitiyanti Dwitiyanti
%A Ermi Ni Putu Ermi Hikmawati
%A Efendi Kriana
%A Riana Riana Puspa Dewi
%A Fernita Fernita Afriyani
%J Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters
%X In Indonesia, Mesona palustris Blume is known as the black cincau (black grass jelly). This plant has
been used for various health condition. This study aims to determine the effectiveness of 70% ethanol
extract from black cincau leaves as anti-hyperlipidemic on hyperlipidemic hamsters. The dried leaves
were extracted using 70% ethanol by maceration method. Syrian hamsters were divided into 7 groups of 4
hamsters), i.e. normal control group, positive control group (fenofibrate 1.235 mg/Kg body weight), positive
control group (atorvastatin 2.4 mg/Kg body weight), negative control group, test groups with 3 dose
variations (780, 1560, and 3120 mg/Kg body weight each day). All groups except normal control group
were induced with high-fat diet for 28 days. Parameters measured were decreased total blood cholesterol,
LDL, triglycerides level, and increased blood HDL level. Treatment was performed for 14 days. The 70%
ethanol extract of black cincau with a dose of 3120 mg/Kg body weight was able to decrease blood total
cholesterol level by 51.49%, blood LDL level by 49.92%, and blood triglyceride level by 45.70%. Extract
with the dose is also able to increase blood HDL level by 29.30%. Fenofibrate was able to decrease blood
triglyceride level by 50.62% and increase blood HDL level by 34.82%, whereas atorvastatin was able to
decrease blood total cholesterol level by 54.34% and blood LDL level by 51.13%. It could be concluded
that the 70% ethanol extract from black cincau leaves is effective as an anti-hyperlipidemic agent in
hyperlipidemic hamster equivalent to positive control group.
%T Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona
palustris Blume Leaves on Male Hamsters