%0 Journal Article
%A Dwitiyanti, Dwitiyanti
%A Ni Putu Ermi Hikmawati, Ermi
%A Kriana, Efendi
%A Riana Puspa Dewi, Riana
%A Fernita Afriyani, Fernita
%A UHAMKA,
%A UHAMKA,
%A UHAMKA,
%F repository:751
%I In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development (MICH-PhD 2018)
%J Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters
%T Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona  palustris Blume Leaves on Male Hamsters
%U http://repository.uhamka.ac.id/id/eprint/751/
%X In Indonesia, Mesona palustris Blume is known as the black cincau (black grass jelly). This plant has  been used for various health condition. This study aims to determine the effectiveness of 70% ethanol  extract from black cincau leaves as anti-hyperlipidemic on hyperlipidemic hamsters. The dried leaves  were extracted using 70% ethanol by maceration method. Syrian hamsters were divided into 7 groups of 4  hamsters), i.e. normal control group, positive control group (fenofibrate 1.235 mg/Kg body weight), positive  control group (atorvastatin 2.4 mg/Kg body weight), negative control group, test groups with 3 dose  variations (780, 1560, and 3120 mg/Kg body weight each day). All groups except normal control group  were induced with high-fat diet for 28 days. Parameters measured were decreased total blood cholesterol,  LDL, triglycerides level, and increased blood HDL level. Treatment was performed for 14 days. The 70%  ethanol extract of black cincau with a dose of 3120 mg/Kg body weight was able to decrease blood total  cholesterol level by 51.49%, blood LDL level by 49.92%, and blood triglyceride level by 45.70%. Extract  with the dose is also able to increase blood HDL level by 29.30%. Fenofibrate was able to decrease blood  triglyceride level by 50.62% and increase blood HDL level by 34.82%, whereas atorvastatin was able to  decrease blood total cholesterol level by 54.34% and blood LDL level by 51.13%. It could be concluded  that the 70% ethanol extract from black cincau leaves is effective as an anti-hyperlipidemic agent in  hyperlipidemic hamster equivalent to positive control group.