@article{repository751,
         journal = {Anti-Hyperlipidemic Effect of 70\% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters},
           title = {Anti-Hyperlipidemic Effect of 70\% Ethanol Extract from Mesona
palustris Blume Leaves on Male Hamsters},
       publisher = {In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development (MICH-PhD 2018)},
             url = {http://repository.uhamka.ac.id/id/eprint/751/},
        abstract = {In Indonesia, Mesona palustris Blume is known as the black cincau (black grass jelly). This plant has
been used for various health condition. This study aims to determine the effectiveness of 70\% ethanol
extract from black cincau leaves as anti-hyperlipidemic on hyperlipidemic hamsters. The dried leaves
were extracted using 70\% ethanol by maceration method. Syrian hamsters were divided into 7 groups of 4
hamsters), i.e. normal control group, positive control group (fenofibrate 1.235 mg/Kg body weight), positive
control group (atorvastatin 2.4 mg/Kg body weight), negative control group, test groups with 3 dose
variations (780, 1560, and 3120 mg/Kg body weight each day). All groups except normal control group
were induced with high-fat diet for 28 days. Parameters measured were decreased total blood cholesterol,
LDL, triglycerides level, and increased blood HDL level. Treatment was performed for 14 days. The 70\%
ethanol extract of black cincau with a dose of 3120 mg/Kg body weight was able to decrease blood total
cholesterol level by 51.49\%, blood LDL level by 49.92\%, and blood triglyceride level by 45.70\%. Extract
with the dose is also able to increase blood HDL level by 29.30\%. Fenofibrate was able to decrease blood
triglyceride level by 50.62\% and increase blood HDL level by 34.82\%, whereas atorvastatin was able to
decrease blood total cholesterol level by 54.34\% and blood LDL level by 51.13\%. It could be concluded
that the 70\% ethanol extract from black cincau leaves is effective as an anti-hyperlipidemic agent in
hyperlipidemic hamster equivalent to positive control group.},
          author = {Dwitiyanti, Dwitiyanti and Ni Putu Ermi Hikmawati, Ermi and Kriana, Efendi and Riana Puspa Dewi, Riana and Fernita Afriyani, Fernita}
}