eprintid: 638
rev_number: 11
eprint_status: archive
userid: 1193
dir: disk0/00/00/06/38
datestamp: 2019-02-21 01:29:52
lastmod: 2020-11-02 05:46:45
status_changed: 2019-02-21 01:29:52
type: article
metadata_visibility: show
creators_name: Rahmah, Elfiyani
creators_name: Yudi, Srifiana
creators_name: Nauval Audia, Andamdewi
creators_id: rahmahelfiyani@uhamka.ac.id
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0002-9233-1557
corp_creators: UHAMKA
corp_creators: UHAMKA
title: Comparison of Carbopol 934 and 941 as Thickener on Diffusion Rate of Ketoconazole Microemulsion
ispublished: pub
subjects: H
divisions: 12
abstract: Aim: This study aimed to compare the diffusion rate of ketoconazole in microemulsion containing carbopol 934 or carbopol 941 as a thickener.
Methods: Ketoconazole microemulsion was made into 7 formulas with various concentrations in each type of thickener, i.e 0.1%, 0.2%, 0.3%, and one formula without thickener. Each formula were evaluated includes organoleptic, pH measurement, viscosity, particle size, potential zeta, surface tension measurement, and diffusion test.
Results: The physical properties of ketoconazole microemulsion showed liquid to gel form, yellow in color, specific odor, pH was in the range of 7.00-7.65, viscosity ranged from 2196-26037 cps, particle size was 13.6-42.2nm, zeta potential was -9.12--18.44 mV, and surface tension 30.7-64 dyne / cm. The diffusion kinetics obtained followed by the higuchi equation for the use of the two thickener, while the ketoconazole microemulsion without thickener (F1) followed the Korsmeyer-peppas equation with a diffusion rate of 9.444 %/minute. The diffusion rate of ketoconazole microemulsion with carbopol 934 (F2, F3, F4) were 4.354, 4.638, and 4.847 %/minute, respectively. Meanwhile, the diffusion rate using carbopol 941 (F5, F6, F7) were 4.695, 4.742, 4.751 %/minute, respectively.
Conclusion: It can be concluded that the diffusion rate (sig ˂ 0,05,) of ketoconazole in microemulsion containing carbopol 941 was faster than diffusion rate of microemulsion containing carbopol 934 at the same concentration in the microemulsion system.
publisher: ISPST
full_text_status: public
publication: Comparison of Carbopol 934 and 941 as Thickener on Diffusion Rate of Ketoconazole Microemulsion
refereed: TRUE
issn: 0975-1459
citation:   Rahmah, Elfiyani dan Yudi, Srifiana dan Nauval Audia, Andamdewi   Comparison of Carbopol 934 and 941 as Thickener on Diffusion Rate of Ketoconazole Microemulsion.  Comparison of Carbopol 934 and 941 as Thickener on Diffusion Rate of Ketoconazole Microemulsion.   ISSN 0975-1459     
document_url: http://repository.uhamka.ac.id/id/eprint/638/1/jpsr112018con23.pdf