%I ISPST
%L repository638
%A Elfiyani Rahmah
%A Srifiana Yudi
%A Andamdewi Nauval Audia
%T Comparison of Carbopol 934 and 941 as Thickener on Diffusion Rate of Ketoconazole Microemulsion
%X Aim: This study aimed to compare the diffusion rate of ketoconazole in microemulsion containing carbopol 934 or carbopol 941 as a thickener.
Methods: Ketoconazole microemulsion was made into 7 formulas with various concentrations in each type of thickener, i.e 0.1%, 0.2%, 0.3%, and one formula without thickener. Each formula were evaluated includes organoleptic, pH measurement, viscosity, particle size, potential zeta, surface tension measurement, and diffusion test.
Results: The physical properties of ketoconazole microemulsion showed liquid to gel form, yellow in color, specific odor, pH was in the range of 7.00-7.65, viscosity ranged from 2196-26037 cps, particle size was 13.6-42.2nm, zeta potential was -9.12--18.44 mV, and surface tension 30.7-64 dyne / cm. The diffusion kinetics obtained followed by the higuchi equation for the use of the two thickener, while the ketoconazole microemulsion without thickener (F1) followed the Korsmeyer-peppas equation with a diffusion rate of 9.444 %/minute. The diffusion rate of ketoconazole microemulsion with carbopol 934 (F2, F3, F4) were 4.354, 4.638, and 4.847 %/minute, respectively. Meanwhile, the diffusion rate using carbopol 941 (F5, F6, F7) were 4.695, 4.742, 4.751 %/minute, respectively.
Conclusion: It can be concluded that the diffusion rate (sig ˂ 0,05,) of ketoconazole in microemulsion containing carbopol 941 was faster than diffusion rate of microemulsion containing carbopol 934 at the same concentration in the microemulsion system.
%J Comparison of Carbopol 934 and 941 as Thickener on Diffusion Rate of Ketoconazole Microemulsion