eprintid: 629
rev_number: 11
eprint_status: archive
userid: 1193
dir: disk0/00/00/06/29
datestamp: 2019-02-04 02:41:55
lastmod: 2020-10-26 07:32:31
status_changed: 2019-02-04 02:41:55
type: article
metadata_visibility: show
creators_name: Ari, Widayanti
creators_name: Hauzal, Halim
creators_name: Muslim, Suardi
creators_id: ariwidayanti@uhamka.ac.id
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0002-9233-1557
corp_creators: UHAMKA
title: FORMULASI MUKOADHESIF NIFEDIPIN MENGGUNAKAN KOMBINASI POLIMER CARBOPOL 943 DAN GELATIN TYPE B
ispublished: pub
subjects: H
divisions: 12
abstract: Mucoadhesive strength test ofpolimer exipient is important for development of oral sustained re/ease with mucoadhesive system to increase bioavailability. Mucoadhesive strength ofniphedipine granule which is prepared by using combination of polymers gelatin and carbopol 934 on rat stomach and intestine had been determined by bioadhesion and wash off test. In this research the various effect of gelatin concentrationson the mucoadhesive strength was determined. Mucoadhesive strength test was conducted with gelatin 2%, 3%, 4%, 5% and as a controll carbopol 934 was used. The study started with the evaluation of characteristics of niphedipine particles with ball mill s/ze. Evaluation of characteristics of the test were wit/? DCS, IR, X-Ray, SEM and then was followed by the preparation ofgranule mucoadhesive niphedipine. t/3e evaluation were granules, bioadhesive test, wash off test and dissolution test. Result showed that F 4 with 5% gelatin could be adhesive to rat stomach and intestine in 5 minutes. The strongest adhesion to stomach and intestine were the granule combination of gelatin 5°Z and carbopol 934 5% with the amount of granule adhesive to stomach and intestine were 94,67% and 98%.Results indicated that the dissolution profit of all the formula did not follow either zero order, first order. The result showed that released of niphedipine from all formulation has followed Higuchi kinetics.
publisher: Farmasains
full_text_status: public
publication: FORMULASI MUKOADHESIF NIFEDIPIN MENGGUNAKAN KOMBINASI POLIMER CARBOPOL 943 DAN GELATIN TYPE B
refereed: TRUE
citation:   Ari, Widayanti dan Hauzal, Halim dan Muslim, Suardi   FORMULASI MUKOADHESIF NIFEDIPIN MENGGUNAKAN KOMBINASI POLIMER CARBOPOL 943 DAN GELATIN TYPE B.  FORMULASI MUKOADHESIF NIFEDIPIN MENGGUNAKAN KOMBINASI POLIMER CARBOPOL 943 DAN GELATIN TYPE B.       
document_url: http://repository.uhamka.ac.id/id/eprint/629/1/Farmasains%20April%202011.pdf