eprintid: 602
rev_number: 7
eprint_status: archive
userid: 1
dir: disk0/00/00/06/02
datestamp: 2019-01-09 04:14:24
lastmod: 2019-01-09 04:14:24
status_changed: 2019-01-09 04:14:24
type: article
metadata_visibility: show
creators_name: Lusi, Putri Dwita
creators_name: Ema, Dewanti
creators_name: Vera, Ladeska
creators_name: Sediarso, Sediarso
creators_name: Adnan, Adnan
creators_name: Rahma, Wulan Sari
creators_id: lusiputridwita@gmail.com
corp_creators: UHAMKA
title: Neuropharmacological activity of nut grass (Cyperus Rotundus L.) rhizome fraction
ispublished: pub
subjects: RS
abstract: The flavonoids content of Cyperus rotundus rhizomes is presumed to show activities on a central nervous system involving GABAergik. This research aimed to further investigate the neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring their hypnotic-sedative and anticonvulsant activities. The exploratory behavior test was performed using the hole-board method, while the motor coordination was assessed using the rotarod test. The results showed that the 70% ethanol fraction of Cyperus rotundus rhizome exhibited significant neuropharmacological activities (p < 0.05). Among the three fractions tested in this research (i.e., ethanol, ethyl acetate, and n-hexane), the ethanol fraction showed the best hypnotic-sedative and anticonvulsant activities. The ethanol fraction of Cyperus rotundus rhizome could shorten the duration of HLE equal to sodium valproate and potentiate phenobarbital-induced sleep by reducing the onset and prolonging the duration of sleep. The highest dose of the 70% ethanol fraction of Cyperus rotundus rhizome (356.7 mg/kg) displayed the best anxiolytic activity, resembling that of diazepam (p>0.05). In conclusion, Cyperus rotundus rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetic drugs.
date: 2018
publisher: pharmaciana
official_url: http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/217/pdf_82
full_text_status: public
publication: Pharmaciana
volume: 8
number: 2
pagerange: 217-224
refereed: TRUE
issn: 2088 4559
citation:   Lusi, Putri Dwita dan Ema, Dewanti dan Vera, Ladeska dan Sediarso, Sediarso dan Adnan, Adnan dan Rahma, Wulan Sari  (2018) Neuropharmacological activity of nut grass (Cyperus Rotundus L.) rhizome fraction.  Pharmaciana, 8 (2).  pp. 217-224.  ISSN 2088 4559     
document_url: http://repository.uhamka.ac.id/id/eprint/602/1/8938-29804-2-PB.pdf