TY  - JOUR
VL  - 8
SP  - 217
PB  - pharmaciana
UR  - http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/217/pdf_82
EP  - 224
AV  - public
N2  - The flavonoids content of Cyperus rotundus rhizomes is presumed to show activities on a central nervous system involving GABAergik. This research aimed to further investigate the neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring their hypnotic-sedative and anticonvulsant activities. The exploratory behavior test was performed using the hole-board method, while the motor coordination was assessed using the rotarod test. The results showed that the 70% ethanol fraction of Cyperus rotundus rhizome exhibited significant neuropharmacological activities (p < 0.05). Among the three fractions tested in this research (i.e., ethanol, ethyl acetate, and n-hexane), the ethanol fraction showed the best hypnotic-sedative and anticonvulsant activities. The ethanol fraction of Cyperus rotundus rhizome could shorten the duration of HLE equal to sodium valproate and potentiate phenobarbital-induced sleep by reducing the onset and prolonging the duration of sleep. The highest dose of the 70% ethanol fraction of Cyperus rotundus rhizome (356.7 mg/kg) displayed the best anxiolytic activity, resembling that of diazepam (p>0.05). In conclusion, Cyperus rotundus rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetic drugs.
A1  - Lusi, Putri Dwita
A1  - Ema, Dewanti
A1  - Vera, Ladeska
A1  - Sediarso, Sediarso
A1  - Adnan, Adnan
A1  - Rahma, Wulan Sari
SN  - 2088 4559
IS  - 2
ID  - repository602
TI  - Neuropharmacological activity of nut grass (Cyperus Rotundus L.) rhizome fraction
Y1  - 2018///
JF  - Pharmaciana
ER  -